NMNH Supplements: What Science Says About Their Health Benefits

NMNH (dihydronicotinamide mononucleotide), also known as reduced NMN, is an advanced NAD+ enhancer. NMNH significantly increases NAD+ levels, making it the next-generation anti-aging supplement. In this article, we explore the effects of NMNH supplementation and provide an in-depth discussion of its safety.

What is NMNH?

NMNH, or dihydronicotinamide mononucleotide, is the reduced form of nicotinamide mononucleotide (NMN). NMNH has recently gained attention for its potential to effectively boost NAD+ levels. Based on animal studies, NMNH performs well in providing NAD+, providing an exciting avenue for NAD supplementation.

Previous Studies on NMNH:

Study demonstrated that NMNH significantly increased NAD+ across various cell types and, in mice, led to a rapid and sustained NAD+ boost in key tissues like the liver, kidney, muscle, brain, and heart.[1]

Another study from the National Library of Medicine reinforced these findings, showing a fivefold NAD+ increase in HepG2 cells. In mice, NMNH administration elevated liver NAD+ levels more effectively than NMN while maintaining a strong safety profile with no toxicity, even at high doses.[2]

UthPeak® has conducted the world’s first, largest, and longest human clinical trial on NMNH (reduced NMN). This 90-day, double-blind, placebo-controlled study involved 80 healthy participants and assessed safety, efficacy, and overall well-being.

Safety Confirmed: No adverse effects were observed on clinical laboratory tests, including blood chemistry, lipid profile, liver function, renal function, and urinalysis.

Biological Age Reduction: Participants experienced a decrease in biological age by up to 5 years.

NAD+ Levels and Energy: A threefold increase in plasma NAD+ levels was noted, along with a 35% improvement in energy levels and a significant reduction in fatigue.

Read more about our phase I clinical studies.

Potential Benefits of UthPeak® NMNH (reduced NMN)

UthPeak® NMNH is the first NMNH brand to conduct clinical studies, leading the world’s first, longest, and largest NMNH clinical trial. Our research aims to provide scientific validation of NMNH’s potential in promoting cellular health and longevity.

Anti-Aging

UthPeak® NMNH plays a key role in the anti-aging research field as the purest form of NMNH (reduced NMN) directly increases NAD+ levels to combat the aging-related decline and stimulates cellular repair and resilience. It has shown promise in boosting NAD+ levels, which may help with cellular repair, improved metabolism, and overall energy.

Cardiovascular Health

UthPeak® NMNH sustains heart health through the healthy condition of blood vessels, the strength of the heart, and the ease of blood flow.

Energy Boost

UthPeak® NMNH makes the function of the mitochondria stronger, ensuring a constant and enduring energy boost.

Brain Function Enhancement

UthPeak® NMNH is a source of energy for neurons and consequently facilitates cognitive functions such as memory, focus, and clarity.

Sleep Quality Improvement

Through cellular health support and metabolic homeostasis, UthPeak® NMNH leads to better sleep quality, regulates sleep patterns, and maintains the normal state of sleep for restoring and restful sleep.

Contact us to to learn more about the benefits of NMH supplements.

Is NMNH Supplements Safe?

With the popularity of NMNH (Reduced NMN), people are paying more attention to its safety. As a leader in the industry, UthPeak® NMNH also upholds the sense of responsibility for consumer safety. Since 2023, we have been focusing on the safety testing of NMNH.

No Acute Oral Toxicity: UthPeak® NMNH has completed toxicology testing of NMNH in 2023. The test confirmed the non-toxicity of NMNH, providing strong evidence for its safety.

Self-GRAS Approval: UthPeak® NMNH has achieved self-affirmed GRAS status, confirming its safety as a dietary supplement. According to Uthpeak, expert evaluations, toxicology studies, and clinical trials support its safe consumption, though it is not FDA-approved. For more details, read our previous post here.

Human Clinical Study Confirmation: In 2024, UthPeak® invited 80 healthy participants to test the safety, tolerability and pharmacokinetics of UthPeak® NMNH (reduced NMN). The results showed that UthPeak® NMNH is safe, with a significant increase in NAD+ and a decrease in biological age indicators, further illustrating the safety and effectiveness of NMNH supplements.

The main research and development focus of UthPeak®’s upcoming Phase II clinical trial in 2025 is to explore more possibilities of NMNH supplements in anti-aging and energy enhancement.

Reference:

[1]Rubén Zapata-Pérez, Alessandra Tammaro. Reduced nicotinamide mononucleotide is a new and potent NAD+ precursor in mammalian cells and mice. The FASEB jurnal. 16 March. 2021. https://doi.org/10.1096/fj.202001826R

[2] Yan Liu, Chengting Luo et al. (2021). Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+ and Suppresses Glycolysis, the TCA Cycle, and Cell Growth. J Proteome Res. 2021 May 7;20(5):2596-2606. doi: 1021/acs.jproteome.0c01037. Epub 2021 Apr 1