A Comparison Between NMN and Reduced Form NMN
NMN and NMNH (Reduced NMN) both belong to the house of NAD+ precursors, one of the scientifically recognized factors impacting the aging process. Due to their function in cellular health energy metabolism and DNA repair, they have been garnering significant attention in the supplement market, especially among health enthusiasts.
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Let's delve into the revolutionary potentials of NMNH (Reduced NMN) and its differentiation from NMN.
Abbreviations
To clarify our discussion, let's define the key abbreviations used in this comparison of NMNH and NMN:
NMNH: Reduced Nicotinamide Mononucleotide
NMN: Nicotinamide Mononucleotide
NAD+: Nicotinamide Adenine Dinucleotide
NR: Nicotinamide Riboside
NMNH
NMNH (Reduced NMN) or dihydronicotinamide mononucleotide, stands for Reduced Nicotinamide Mononucleotide.
Studies in animal models suggest that NMNH (Reduced NMN) has the potential to rapidly and significantly increase NAD levels, surpassing NR, presenting an exciting avenue for NAD replenishment.
NMN
NMN is called Nicotinamide Mononucleotide and is a NAD+ booster with proven benefits.
NMN acts as a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a critical coenzyme involved in energy production, DNA repair, and cellular regulation.
Research Highlights on NMNH
as a Potent NAD+ Booster
Two independent studies, published in prominent scientific journals, have demonstrated the efficacy of reduced nicotinamide mononucleotide (NMNH) as a powerful enhancer of cellular NAD+ levels. Below is a synthesis of their key findings:
Study Published in the Federation of American Societies for Experimental Biology (FASEB) Journal
This research revealed NMNH’s superior ability to elevate NAD+ compared to NMN (nicotinamide mononucleotide):
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In Vitro Results:
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NMNH supplementation significantly increased NAD+ content across multiple cell types (e.g., AML12, T37i, HepG2), outperforming NMN at equivalent concentrations.
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In Vivo Results:
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Administering NMNH to mice triggered a rapid and sustained surge in NAD+ levels within whole blood.
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Elevated NAD+ was also observed in critical tissues, including the liver, kidney, muscle, brain, brown adipose tissue, and heart.
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Study Published in the National Library of Medicine
This work further validated NMNH’s NAD+ boosting potential and safety profile:
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In Vitro Findings:
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Treatment with 100μM NMNH increased NAD+ levels in HepG2 cells by 5-fold. Similar dose- and time-dependent effects were observed in ES-2 and 3T3-L1 cell lines.
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In Vivo Outcomes:
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Intraperitoneal injection of NMNH (340 mg/kg) in male C57BL/6J mice elevated liver NAD+ levels to 4 times the control group and 1.5 times the NMN-treated group.
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Oral NMNH administration also robustly increased hepatic NAD+ without inducing liver toxicity or adverse effects, even at high doses.
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NMNH V.S. NMN (Anti-Aging Effect)
Our phase I clinical studies have uncovered a remarkable discovery regarding NMNH (Reduced NMN). These studies have shown that NMNH can reduce biological age indicators by up to five years. This finding highlights the promising benefits of NMNH in the context of anti-aging effects.
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While NMNH shows significant potential, our ongoing phase II research aims to explore its benefits further. Meanwhile, comprehensive toxicology, preclinical studies, and self-gras certification have thoroughly examined its safety profile, providing a solid foundation for its continued development.
NMNH V.S. NMN (Multi-Tissue NAD+ Rise)
NMNH (Reduced NMN) demonstrates superior efficiency in boosting NAD+ levels. In studies with mice, NMNH (Reduced NMN) leads to a swift and sustained surge in NAD+ throughout the bloodstream, while also significantly increasing NAD+ concentrations in critical tissues such as the liver, kidney, muscle, brain, brown adipose tissue, and heart.
Comparison Between NMNH and NMN
When comparing NMNH and NMN, several key differences emerge:
Molecular and Chemical Composition
The molecular structure and chemical composition of NMNH and NMN are fundamentally different. NMNH is a reduced form of NMN, a modification that significantly enhances its ability to raise NAD+ levels in the body. This structural difference is key to NMNH's enhanced efficacy, enabling more efficient cellular uptake and utilization, which in turn contributes to more effective NAD+ replenishment.
Health Implications
The impact of NMNH on health appears to be more extensive and potent compared to NMN. NMNH's capability to influence multiple tissues and sustain NAD+ boosting points to its potential for offering comprehensive health benefits. Particularly in the realms of anti-aging and cellular health, NMNH's multifaceted influence suggests that it could be more effective in combating age-related decline and supporting cellular functions across a wider array of body tissues.
NAD+ Level Rise
In vitro studies have demonstrated that NMNH (Reduced NMN) can significantly boost NAD+ levels. NAD+ plays a vital role in essential metabolic functions, DNA repair, and energy production. Given NMNH’s ability to effectively increase NAD+ levels, it is expected to offer notable health benefits, including improved cellular energy and enhanced repair and maintenance of cellular components.
Dosage Considerations
Both NMNH and NMN are undergoing extensive testing to determine their optimal dosages. NMNH's enhanced potency potentially allows for lower dosage requirements compared to NMN, which can directly impact the end-consumer experience. A smaller dosage of NMNH means that supplements can be produced in smaller capsules or tablets, making them more convenient and appealing for daily consumption. This precise dosage determination is crucial for guiding the practical application of health supplements and treatments, ensuring users receive effective, manageable, and consumer-friendly options for their wellness routines.
NMNH (Reduced NMN) has demonstrated the potential to surpass conventional NAD+ precursors in terms of efficacy in cellular health enhancement. Learn how we ensure the ultimate safety and efficacy through the UthPeak™ preclinical and clinical trials and studies.