A Comparison Between NMN and Reduced Form NMN
NMN and NMNH (Reduced NMN) both belong to the house of NAD+ precursors, one of the scientifically recognized factors impacting the aging process. Due to their function in cellular health energy metabolism and DNA repair, they have been garnering significant attention in the supplement market, especially among health enthusiasts.
Let's delve into the revolutionary potentials of NMNH (Reduced NMN) and its differentiation from NMN.
Abbreviations
To clarify our discussion, let's define the key abbreviations used in this comparison of NMNH and NMN:
NMNH: Reduced Nicotinamide Mononucleotide
NMN: Nicotinamide Mononucleotide
NAD+: Nicotinamide Adenine Dinucleotide
NR: Nicotinamide Riboside
NMNH
NMNH (Reduced NMN) or dihydronicotinamide mononucleotide, stands for Reduced Nicotinamide Mononucleotide.
Studies in animal models suggest that NMNH (Reduced NMN) has the potential to rapidly and significantly increase NAD levels, surpassing NR, presenting an exciting avenue for NAD replenishment.
NMN
NMN is called Nicotinamide Mononucleotide and is a NAD+ booster with proven benefits.
NMN acts as a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a critical coenzyme involved in energy production, DNA repair, and cellular regulation.
Research Highlights on NMNH
as a Potent NAD+ Booster
Two independent studies, published in prominent scientific journals, have demonstrated the efficacy of reduced nicotinamide mononucleotide (NMNH) as a powerful enhancer of cellular NAD+ levels. Below is a synthesis of their key findings:
Study Published in the Federation of American Societies for Experimental Biology (FASEB) Journal
This research revealed NMNH’s superior ability to elevate NAD+ compared to NMN (nicotinamide mononucleotide):
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In Vitro Results:
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NMNH supplementation significantly increased NAD+ content across multiple cell types (e.g., AML12, T37i, HepG2), outperforming NMN at equivalent concentrations.
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In Vivo Results:
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Administering NMNH to mice triggered a rapid and sustained surge in NAD+ levels within whole blood.
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Elevated NAD+ was also observed in critical tissues, including the liver, kidney, muscle, brain, brown adipose tissue, and heart.
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Study Published in the National Library of Medicine
This work further validated NMNH’s NAD+ boosting potential and safety profile:
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In Vitro Findings:
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Treatment with 100μM NMNH increased NAD+ levels in HepG2 cells by 5-fold. Similar dose- and time-dependent effects were observed in ES-2 and 3T3-L1 cell lines.
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In Vivo Outcomes:
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Intraperitoneal injection of NMNH (340 mg/kg) in male C57BL/6J mice elevated liver NAD+ levels to 4 times the control group and 1.5 times the NMN-treated group.
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Oral NMNH administration also robustly increased hepatic NAD+ without inducing liver toxicity or adverse effects, even at high doses.
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NMNH V.S. NMN (Anti-Aging Effect)
Our phase I clinical studies have uncovered a remarkable discovery regarding NMNH (Reduced NMN). These studies have shown that NMNH can reduce biological age indicators by up to five years. This finding highlights the promising benefits of NMNH in the context of anti-aging effects.
While NMNH shows significant potential, our ongoing phase II research aims to explore its benefits further. Meanwhile, comprehensive toxicology, preclinical studies, and self-gras certification have thoroughly examined its safety profile, providing a solid foundation for its continued development.
NMNH V.S. NMN (Multi-Tissue NAD+ Rise)
NMNH (Reduced NMN) demonstrates superior efficiency in boosting NAD+ levels. In studies with mice, NMNH (Reduced NMN) leads to a swift and sustained surge in NAD+ throughout the bloodstream, while also significantly increasing NAD+ concentrations in critical tissues such as the liver, kidney, muscle, brain, brown adipose tissue, and heart.
Comparison Between NMNH and NMN
When comparing NMNH and NMN, several key differences emerge:
Molecular and Chemical Composition
The molecular structure and chemical composition of NMNH and NMN are fundamentally different. NMNH is a reduced form of NMN, a modification that significantly enhances its ability to raise NAD+ levels in the body. This structural difference is key to NMNH's enhanced efficacy, enabling more efficient cellular uptake and utilization, which in turn contributes to more effective NAD+ replenishment.
Health Implications
The impact of NMNH on health appears to be more extensive and potent compared to NMN. NMNH's capability to influence multiple tissues and sustain NAD+ boosting points to its potential for offering comprehensive health benefits. Particularly in the realms of anti-aging and cellular health, NMNH's multifaceted influence suggests that it could be more effective in combating age-related decline and supporting cellular functions across a wider array of body tissues.
NAD+ Level Rise
In vitro studies have demonstrated that NMNH (Reduced NMN) can significantly boost NAD+ levels. NAD+ plays a vital role in essential metabolic functions, DNA repair, and energy production. Given NMNH’s ability to effectively increase NAD+ levels, it is expected to offer notable health benefits, including improved cellular energy and enhanced repair and maintenance of cellular components.
Dosage Considerations
Both NMNH and NMN are undergoing extensive testing to determine their optimal dosages. NMNH's enhanced potency potentially allows for lower dosage requirements compared to NMN, which can directly impact the end-consumer experience. A smaller dosage of NMNH means that supplements can be produced in smaller capsules or tablets, making them more convenient and appealing for daily consumption. This precise dosage determination is crucial for guiding the practical application of health supplements and treatments, ensuring users receive effective, manageable, and consumer-friendly options for their wellness routines.
NMNH (Reduced NMN) has demonstrated the potential to surpass conventional NAD+ precursors in terms of efficacy in cellular health enhancement. Learn how we ensure the ultimate safety and efficacy through the UthPeak™ preclinical and clinical trials and studies.
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Is NAD approved by FDA?Currently, NAD and its precursors, like NMNH and NMN, fall under the category of dietary supplements. The Food and Drug Administration (FDA) doesn’t grant approval to dietary supplements in the same manner it does for pharmaceutical drugs. Instead, it monitors the market for any supplements that might pose safety concerns or make unsubstantiated health claims. Manufacturers are responsible for ensuring their products are safe and that any health claims are supported by evidence. While NAD supplements are available on the market, consumers should look for products from reputable sources to ensure quality and safety.
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Where can I find the published clinical data on NMNH?We are currently conducting a Phase II clinical trial. Our findings from both Phase I and Phase II will be included in our upcoming paper submission. The publication date is yet to be determined; however, we will continue to update the results on our website and social media platforms. Contact us to stay informed.
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Is NMNH the same as NMN?NMNH (Reduced Nicotinamide Mononucleotide) and NMN (Nicotinamide Mononucleotide) are related but distinct compounds involved in the body's NAD+ biosynthesis pathway. NMNH is the reduced form of NMN, meaning it has undergone a bio-reduction reaction that changes its molecular structure. NMNH is metabolized through a different, NRK and NAMPT-independent, pathway, which potentially enhances NMNH's ability to increase NAD+ levels to a much higher extent and faster than NMN. While both are precursors to NAD+ and share the goal of boosting NAD+ levels within the body, their differences in chemical structures influence their stability and effectiveness in supplement forms.
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Are there any dangers taking NAD supplements?Like with any supplement, there can be risks associated with taking NAD supplements, especially if taken inappropriately or in excessive amounts. Potential dangers could include interactions with medications, underlying health conditions, or side effects such as nausea, fatigue, and headaches in some individuals. However, when used under the guidance of a healthcare professional and within recommended dosages, NAD supplements are generally considered safe for most people. It's crucial to consult with a healthcare provider before starting any new supplement regimen.
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Are NMNH self-GRAS approved?UthPeak® NMNH (Reduced NMN) is the first NMNH brand to receive self-GRAS approval, meaning it has been assessed by a scientific expert committee for safety. It is now recognized as safe for use in selected conventional foods, dietary supplements, and medical foods.
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How do NMNH and NMN affect NAD+ levels?NMNH (Reduced NMN) and NMN both help increase NAD+ levels in the body, but they do so in slightly different ways. NMN directly boosts NAD+ through the salvage pathway, a process where existing NAD+ is recycled. In contrast, NMNH's reduced form may enable additional or more efficient pathways to elevate NAD+ levels. However, more research is needed to fully understand how NMNH is metabolized and how it compares to NMN in effectiveness.
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Can NMNH be obtained through diet?Currently, NMNH is not typically obtained through diet. It is developed and administered as a supplement, primarily due to its specific molecular structure that is not readily available in dietary sources. As a specialized compound, NMNH is usually manufactured through a controlled process to ensure its efficacy and purity for supplemental use.
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Are there any side effects of NMNH vs NMN?NMNH (reduced NMN) and NMN are generally regarded as safe, backed by findings from completed toxicology and clinical studies. As NAD+ supplements, they are typically safe for daily use. However, potential side effects may include nervousness, headaches, and fatigue. It is crucial to consult with a healthcare provider to establish the correct dosage and usage guidelines.
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What are the implications of the difference between NMNH and NMN?NMNH (Reduced NMN) and NMN are distinct chemical compounds, but both can effectively raise NAD+ levels. Our ongoing clinical studies indicate that NMNH (Reduced NMN) may play a significant role in reducing biological age markers and offering other potential advantages.
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Are NMNH and NMN the same thing?NMNH (Reduced NMN) and NMN (Nicotinamide Mononucleotide) are distinct chemical compounds. NMNH is the reduced form of NMN, differing in its chemical structure by the addition of a hydrogen atom.
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Can NMNH impact multiple tissues and organs?Indeed, NMNH can impact multiple tissues and organs. Its ability to increase NAD+ levels is not limited to a single type of tissue or organ. NMNH has been observed to enhance NAD+ levels in a variety of tissues, including the heart, brain and muscle, indicating its potential for widespread cellular support.
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What makes UthPeak® NMNH unique in the market?UthPeak® NMNH boasts an advanced, patent-pending crystalline form, offering higher purity and stability compared to standard NMN supplements. This distinctive characteristic ensures it delivers enhanced and sustained NAD+ boosting effects, positioning UthPeak® as a frontrunner in the NAD+ supplement market.
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How long does the NAD+ boost from UthPeak® NMNH last?UthPeak® NMNH is notable for its longevity. It raises NAD+ levels for up to 6 hours and maintains them at a high level for about 24 hours. This extended duration surpasses that of many other NAD+ precursors, offering prolonged benefits for users.
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How does UthPeak® NMNH differ from other NAD+ precursors?UthPeak® NMNH sets itself apart from other NAD+ precursors primarily through its exceptional potency. As a reduced form of nicotinamide mononucleotide (NMN), it can increase NAD+ levels up to ten times more effectively than similar compounds. The proprietary crystalline structure of UthPeak® NMNH enhances its stability, ensuring it maintains its integrity and effectiveness in boosting NAD+ levels.
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